Irreversible electroporation (IRE) is a non-thermal tissue ablation modality.
Unlike reversible electroporation, it acts through the delivery of numerous high voltage electrical pulses that create permanent nano-pores in the cell membrane, altering homeostasis. Disruption of cellular homeostasis initiates an apoptotic process that leads to cell death.
This procedure does not involve the administration of any chemotherapy drugs, so the effects are exclusively physical.
IRE is mainly used in oncology for ablation of deep organs (liver, pancreas) and, unlike electrochemotherapy, it's not indicated for the treatment of skin and bone lesions.
Because of the specific advantages of this non-thermal ablation procedure, IRE has recently been used in the treatment of atrial fibrillation within clinical trials.