ELECTRO-GENE-TRANSFER (EGT) IS THE TRANSFER OF GENETIC MATERIAL (NUCLEIC ACIDS, PLASMIDS) INTO CELLS BY APPLYING ELECTRICAL PULSES.

Electrical pulses in EGT mode serve a dual function:

• Electroporation of target cells
• Electrophoretic transport of genetic material across the cell membrane

Once inside the cell, the nucleic acid will give rise to one or more proteins that will produce the desired therapeutic or prophylactic effect. 

The main areas of application of EGT are:

IGEA has developed two distinct pulse generators to efficiently deliver nucleic acids into cells:

• Genedrive, for pre-clinical in-vitro and in-vivo experiments
• Cliniporator® FULL, approved for human use

Both generators allow users to customise the electrical protocols, changing the amplitude, duration and frequency of pulses in order to optimise nucleic acid transfer.